Pair page
Bronchogen with Epithalon
Mechanism-tag overlap and published literature for Bronchogen and Epithalon, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
khavinson-bronchial-bioregulator
pineal-tetrapeptide-khavinson-bioregulator
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying Bronchogen and Epithalon have published these mechanism-level observations. Not a co-administration recommendation.
Epithalon (AEDG, pineal/telomerase-axis bioregulator) is the most-studied Khavinson peptide and is commonly included in longevity-oriented bioregulator stacks alongside tissue-specific peptides such as Bronchogen.
Quick facts
Bronchogen
Epithalon
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2021 | Bronchogen | Khavinson VKh, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053. PMID: 34834147. DOI: 10.3390/molecules26227053. PMID 34834147 | systematic review |
| 2006 | Bronchogen | Gumen AV, Kozinets IA, Shanin SN, Malinin VV, Rybakina EG. Production of lymphocyte-activating factors by mouse macrophages during aging and under the effect of short peptides. Bulletin of Experimental Biology and Medicine. 2006;142(3):360-362. PMID: 17266159. PMID 17266159 | preclinical, in vivo |
| 2016 | Bronchogen | Linkova NS, Drobintseva AO, Orlova OA, Kuznetsova EP, Polyakova VO, Kvetnoy IM, Khavinson VKh. Peptide regulation of skin fibroblast functions during their aging in vitro. Bulletin of Experimental Biology and Medicine. 2016;161(1):175-178. PMID: 27259486. (Methodology reference… PMID 27259486 | preclinical, in vitro |
| 2011 | Bronchogen | Fedoreyeva LI, Kireev II, Khavinson VKh, Vanyushin BF. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and the specific interaction of the peptides with deoxyribooligonucleotides and DNA in vitro. Biochemistry (Moscow). 2011;76(11):1210-1219. PM… PMID 22117548 | preclinical, in vitro |
| 2012 | Bronchogen | Khavinson VKh, Solov'ev AIu, Zhilinskii DV. Molecular mechanism of the peptide regulation of gene expression: a review. Advances in Gerontology. 2012;25(3):447-456. PMID: 23289233. (Program mechanism review including AEDL-class peptides.) PMID 23289233 | mechanism / discovery |
| 2003 | Bronchogen | Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine. 2003;135(6):590-592. PMID: 12937682. (Sibling-peptide methodology reference.) PMID 12937682 | mechanism / discovery |
| 2002 | Bronchogen | Khavinson VKh. Peptides and ageing. Neuroendocrinology Letters. 2002;23(Suppl 3):11-144. PMID: 12496732. (Program-level review of the Khavinson short-peptide bioregulator framework.) PMID 12496732 | review |
| 2020 | Bronchogen | Khavinson V, Linkova N, Diatlova A, Trofimova S. Peptide Regulation of Cell Differentiation. Stem Cell Reviews and Reports. 2020;16(1):118-125. PMID: 31813120. DOI: 10.1007/s12015-019-09938-8. PMID 31813120 | bioregulator literature |
| 2016 | Bronchogen | Vanyushin BF, Khavinson VKh. Short Biologically Active Peptides as Epigenetic Modulators of Gene Activity. In: Doerfler W, Casadesús J (eds), Epigenetics — A Different Way of Looking at Genetics. Springer International Publishing, 2016. DOI: 10.1007/978-3-319-27186-6_5. | bioregulator literature |
| 2012 | Bronchogen | Khavinson VKh, Linkova NS, Polyakova VO, Kheifets OV, Tarnovskaya SI, Kvetnoy IM. Peptides tissue-specifically stimulate cell differentiation during their aging. Bulletin of Experimental Biology and Medicine. 2012;153(1):148-151. PMID: 22808513. PMID 22808513 | bioregulator literature |
| 2011 | Bronchogen | Monaselidze JR, Khavinson VKh, Gorgoshidze MZ, Khachidze DG, Lomidze EM, Jokhadze TA, Lezhava TA. Effect of the peptide Bronchogen (Ala-Asp-Glu-Leu) on DNA thermostability. Bulletin of Experimental Biology and Medicine. 2011;150(3):375-377. DOI: 10.1007/s10517-011-1144-z. | bioregulator literature |
| 2010 | Bronchogen | Anisimov VN, Khavinson VKh. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010;11(2):139-149. PMID: 19633997. PMID 19633997 | bioregulator literature |
| 2010 | Epithalon | Korkushko OV, Khavinson VKh, Shatilo VB, Antonyk-Sheglova IA. Peptide geroprotector Epitalamin: effects on vascular endothelial function in elderly patients. Adv Gerontol. 2010;23(3):440-446. | human study |
| 2004 | Epithalon | Khavinson VKh, Bondarev IE, Butyugov AA, Smirnova TD. Peptide promotes overcoming of the division limit in human somatic cell. Bull Exp Biol Med. 2004;137(5):503-506. | human study |
| 2003 | Epithalon | Khavinson VKh, Morozov VG. Peptides of pineal gland and thymus prolong human life. Neuro Endocrinol Lett. 2003;24(3-4):233-240. PMID: 14523363. (266-patient elderly mortality cohort.) PMID 14523363 | human study |
| 2021 | Epithalon | Khavinson V, Ilina A, Kraskovskaya N, Linkova N, Kolchina N, Mikhailova N, Petukhov M. Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease. Pharmaceuticals (Basel). 2021;14(6):515. | preclinical, in vivo |
| 2004 | Epithalon | Labunets IF, Butenko GM, Dragunova VA, Magdich LV, Khavinson VKh. Effect of epithalamin, thymalin, and tocopherol on age-associated involution of the pineal gland in rats. Bull Exp Biol Med. 2004;137(5):510-512. | preclinical, in vivo |
| 2003 | Epithalon | Anisimov VN, Khavinson VKh, Provinciali M, Alimova IN, Baturin DA, Popovich IG, Zabezhinski MA, Imyanitov EN, Mancini R, Franceschi C. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4)… PMID 14501183 | preclinical, in vivo |
| 2003 | Epithalon | Kossoy G, Zandbank J, Tendler E, Anisimov V, Khavinson V, Popovich I, Zabezhinski M, Zusman I, Ben-Hur H. Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa. Int J Mol Med. 2003;12(4):473-477. PMID: 12964019. PMID 12964019 | preclinical, in vivo |
| 2025 | Epithalon | Al-Dulaimi MS, et al. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. 2025. PMID: 40908429. PMC12411320. (Modern Western-lab replication of the central telomerase-activation claim.) PMID 40908429 | mechanism / discovery |
| 2017 | Epithalon | Khavinson V, Popovich I. Short peptides regulate gene expression, protein synthesis and enhance life span. In: Understanding the Aging Process and Age-Related Diseases. Academic Press; 2017. | mechanism / discovery |
| 2016 | Epithalon | Khavinson VKh, Linkova NS, Tarnovskaia SI. Short peptides regulate gene expression. Bull Exp Biol Med. 2016;162(2):288-292. | mechanism / discovery |
| 2017 | Epithalon | Khavinson VKh, Kopylov AT, Vaskovsky BV, Ryzhak GA, Lin'kova NS. Identification of peptide AEDG in the polypeptide complex of the pineal gland. Bull Exp Biol Med. 2017;164(1):41-43. | bioregulator literature |
| 2017 | Epithalon | Khavinson VKh, Sibarov DA, Tsai PY, Adushkin BV, Ryzhak GA. Short peptides stimulate serotonin release and attenuate hyperexcitation in the hippocampus. Bull Exp Biol Med. 2017;163(4):539-541. | bioregulator literature |
Related pair pages
More research context
Frequently asked
Have Bronchogen and Epithalon been studied together?
Researchers have published mechanistic-level co-administration discussion of Bronchogen and Epithalon. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do Bronchogen and Epithalon share?
Bronchogen and Epithalon do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of Bronchogen and Epithalon?
Bronchogen: Not approved. Epithalon: Not approved. FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on Bronchogen and Epithalon?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the Bronchogen profile and the Epithalon profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026