Pair page
MGF with PEG-MGF
Mechanism-tag overlap and published literature for MGF and PEG-MGF, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
igf-1-splice-variant-satellite-cell-activator
pegylated-igf-1-splice-variant
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying MGF and PEG-MGF have published these mechanism-level observations. Not a co-administration recommendation.
Native MGF provides a sharp, high-concentration local pulse post-workout (mimicking physiological mechano-response). PEG-MGF provides sustained low-concentration systemic exposure. These are two different pharmacological strategies, not interchangeable; choosing one rather than combining is more mechanistically coherent.
Quick facts
MGF
PEG-MGF
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2009 | MGF | Stavropoulou A, Halapas A, Sourla A, Philippou A, Papageorgiou E, Papalois A, Koutsilieris M. IGF-1 expression in infarcted myocardium and MGF E peptide actions in rat cardiomyocytes in vitro. Mol Med. 2009;15(5-6):127-135. PMID: 19242589. PMID 19242589 | preclinical, in vivo |
| 2007 | MGF | Philippou A, Maridaki M, Halapas A, Koutsilieris M. The role of the insulin-like growth factor 1 (IGF-1) in skeletal muscle physiology. In Vivo. 2007;21(1):45-54. PMID: 17354613. PMID 17354613 | preclinical, in vivo |
| 2003 | MGF | Hill M, Goldspink G. Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage. J Physiol. 2003;549(Pt 2):409-418. PMID: 12692182. DOI: 10.1113/jphysiol.2002.035832. PMID 12692182 | preclinical, in vivo |
| 2002 | MGF | Yang SY, Goldspink G. Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation. FEBS Lett. 2002;522(1-3):156-160. PMID: 12095642. DOI: 10.1016/s0014-5793(02)02918-6. PMID 12095642 | preclinical, in vitro |
| 2010 | MGF | Matheny RW Jr, Nindl BC, Adamo ML. Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration. Endocrinology. 2010;151(3):865-875. PMID: 20130113. PMID 20130113 | mechanism / discovery |
| 2025 | MGF | WADA. World Anti-Doping Code: The 2025 Prohibited List. Section S2 — Peptide hormones, growth factors, related substances and mimetics. World Anti-Doping Agency. | regulatory / registry |
| 2013 | MGF | Brisson BK, Barton ER. New modulators for IGF-I activity within IGF-I processing products. Front Endocrinol (Lausanne). 2013;4:42. PMID: 23626586. PMID 23626586 | research article |
| 2009 | MGF | Pfeffer LA, Brisson BK, Lei H, Barton ER. The insulin-like growth factor (IGF)-I E-peptides modulate cell entry of the mature IGF-I protein. Mol Biol Cell. 2009;20(17):3810-3817. PMID: 19605555. PMID 19605555 | research article |
| 2008 | MGF | Carpenter V, Matthews K, Devlin G, Stuart S, Jensen J, Conaglen J, Jeanplong F, Goldspink P, Yang SY, Goldspink G, Bass J, McMahon C. Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction. Heart Lung Circ. 2008;17(1):33-39. PMID: 17881288. DOI: 10… PMID 17881288 | research article |
| 2007 | MGF | Mills P, Dominique JC, Lafrenière JF, Bouchentouf M, Tremblay JP. A synthetic mechano growth factor E peptide enhances myogenic precursor cell transplantation success. Am J Transplant. 2007;7(10):2247-2259. PMID: 17711551. PMID 17711551 | research article |
| 2007 | MGF | Philippou A, Halapas A, Maridaki M, Koutsilieris M. Type I insulin-like growth factor receptor signaling in skeletal muscle regeneration and hypertrophy. J Musculoskelet Neuronal Interact. 2007;7(3):208-218. PMID: 17906394. PMID 17906394 | research article |
| 2005 | MGF | Goldspink G. Mechanical signals, IGF-I gene splicing, and muscle adaptation. Physiology (Bethesda). 2005;20:232-238. PMID: 16024512. DOI: 10.1152/physiol.00004.2005. PMID 16024512 | research article |
| 2009 | PEG-MGF | Riddoch-Contreras J, Yang SY, Dick JR, Goldspink G, Orrell RW, Greensmith L. Mechano-growth factor, an IGF-I splice variant, rescues motoneurons and improves muscle function in SOD1(G93A) mice. Exp Neurol. 2009;215(2):281-289. PMID: 19056385. PMID 19056385 | preclinical, in vivo |
| 2005 | PEG-MGF | Shavlakadze T, Winn N, Rosenthal N, Grounds MD. Reconciling data from transgenic mice that overexpress IGF-I specifically in skeletal muscle. Growth Horm IGF Res. 2005;15(1):4-18. PMID: 15701567. PMID 15701567 | preclinical, in vivo |
| 2003 | PEG-MGF | Hill M, Goldspink G. Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage. J Physiol. 2003;549(Pt 2):409-418. PMID: 12692175. PMID 12692175 | preclinical, in vivo |
| 2002 | PEG-MGF | Yang SY, Goldspink G. Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation. FEBS Lett. 2002;522(1-3):156-160. PMID: 12095634. PMID 12095634 | preclinical, in vitro |
| 2005 | PEG-MGF | Goldspink G. Mechanical signals, IGF-I gene splicing, and muscle adaptation. Physiology (Bethesda). 2005;20:232-238. PMID: 16024702. (Foundational review of MGF / IGF-1Ec biology.) PMID 16024702 | review |
| 2026 | PEG-MGF | World Anti-Doping Agency. The 2026 Prohibited List. Montreal: WADA; 2026. (Class S2 prohibition — peptide hormones, growth factors, and mimetics including MGF analogs.) | regulatory / registry |
| 2015 | PEG-MGF | Yang Q, Lai SK. Anti-PEG immunity: emergence, characteristics, and unaddressed questions. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015;7(5):655-677. PMID: 25707913. (Anti-PEG antibody review relevant to chronic PEG-MGF exposure.) PMID 25707913 | research article |
| 2014 | PEG-MGF | Philippou A, Maridaki M, Pneumaticos S, Koutsilieris M. The complexity of the IGF1 gene splicing, posttranslational modification and bioactivity. Mol Med. 2014;20:202-214. PMID: 24637928. PMID 24637928 | research article |
| 2010 | PEG-MGF | Knop K, Hoogenboom R, Fischer D, Schubert US. Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. Angew Chem Int Ed Engl. 2010;49(36):6288-6308. PMID: 20648499. (PEG pharmacology including anti-PEG antibody context.) PMID 20648499 | research article |
| 2008 | PEG-MGF | Carpenter V, Matthews K, Devlin G, Stuart S, Jensen J, Conaglen J, Jeanplong F, Goldspink P, Yang SY, Goldspink G, Bass J, McMahon C. Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction. Heart Lung Circ. 2008;17(1):33-39. PMID: 17581797. PMID 17581797 | research article |
| 2007 | PEG-MGF | Mills P, Dominique JC, Lafrenière JF, Bouchentouf M, Tremblay JP. A synthetic mechano growth factor E Peptide enhances myogenic precursor cell transplantation success. Am J Transplant. 2007;7(10):2247-2259. PMID: 17845562. PMID 17845562 | research article |
| 2007 | PEG-MGF | Mills P, Lafrenière JF, Benabdallah BF, El Fahime el M, Tremblay JP. A new pro-migratory activity on human myogenic precursor cells for a synthetic peptide within the E domain of the mechano growth factor. Exp Cell Res. 2007;313(3):527-537. PMID: 17156777. PMID 17156777 | research article |
Related pair pages
More research context
Frequently asked
Have MGF and PEG-MGF been studied together?
Researchers have published mechanistic-level co-administration discussion of MGF and PEG-MGF. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do MGF and PEG-MGF share?
MGF and PEG-MGF do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of MGF and PEG-MGF?
MGF: Not approved. PEG-MGF: Research only; no IND. FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on MGF and PEG-MGF?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the MGF profile and the PEG-MGF profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026