Pair page
N-Acetyl Selank with Semax
Mechanism-tag overlap and published literature for N-Acetyl Selank and Semax, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
tuftsin-family-anxiolytic
acth-analogneuroprotectivenootropic
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying N-Acetyl Selank and Semax have published these mechanism-level observations. Not a co-administration recommendation.
Parent form of Adamax; often co-dosed with parent or acetylated Selank. Russian neurology literature frequently evaluates Semax + Selank as a standard outpatient pair in stress-related disorders.
Quick facts
N-Acetyl Selank
Semax
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2008 | N-Acetyl Selank | Uchakina ON, Uchakin PN, Miasoedov NF, Andreeva LA. Immunomodulatory effects of selank in patients with anxiety-asthenic disorders. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(5):71-75. PMID: 18577925. PMID 18577925 | human study |
| 2017 | N-Acetyl Selank | Medvedev VE, Tereshchenko OV, Kost NV, Ter-Israelyan AY, Gushanskaya EV, Chobanu IK, Sokolov OY, Miasoedov NF. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behav Neurol. 2017;2017:5091027. PMC5322660. | preclinical, in vivo |
| 2009 | N-Acetyl Selank | Semenova TP, Kozlovskii II, Zakharova NM, Kozlovskaia MM. Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA. Eksp Klin Farmakol. 2009;72(4):6-8. PMID: 19803388. PMID 19803388 | preclinical, in vivo |
| 2008 | N-Acetyl Selank | Inozemtseva LS, Karpenko EA, Dolotov OV, Levitskaya NG, Kamensky AA, Andreeva LA, Grivennikov IA. Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo. Dokl Biol Sci. 2008;421:241-243. PMID: 18841774. PMID 18841774 | preclinical, in vivo |
| 2002 | N-Acetyl Selank | Kozlovskii II, Danchev ND. The optimizing action of the synthetic peptide selank on an active avoidance reflex in rats. Zh Vyssh Nerv Deiat Im I P Pavlova. 2002;52(5):579-584. PMID: 12449037. PMID 12449037 | preclinical, in vivo |
| 1998 | N-Acetyl Selank | Seredenin SB, Kozlovskaia MM, Blednov IuA, Kozlovskii II, Semenova TP, Czabak-Garbacz R. The anxiolytic action of an analog of the endogenous peptide tuftsin on inbred mice with different phenotypes of the emotional stress reaction. Zh Vyssh Nerv Deiat Im I P Pavlova. 1998;48(1)… PMID 9612605 | preclinical, in vivo |
| 2016 | N-Acetyl Selank | Volkova A, Shadrina M, Kolomin T, Andreeva L, Limborska S, Myasoedov N, Slominsky P. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016 Feb 18;7:31. PMID: 26924986. PMID 26924986 | research article |
| 2014 | N-Acetyl Selank | Kolomin T, Morozova M, Volkova A, Shadrina M, Andreeva L, Slominsky P, Limborska S, Myasoedov N. The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action. Mol Immunol. 2014;58(1):50-55. PMID: 24275703. PMID 24275703 | research article |
| 2010 | N-Acetyl Selank | Andreeva LA, Nagaev IY, Mezentseva MV, Shapoval IM, Podchernyaeva RY, Shcherbenko VE, Potapova LA, Rusakova EV, Miasoedov NF. Antiviral properties of structural fragments of the peptide Selank. Dokl Biol Sci. 2010;431:86-88. PMID: 20506848. PMID 20506848 | research article |
| 2009 | N-Acetyl Selank | Ershov FI, Uchakin PN, Uchakina ON, Mezentseva MV, Alekseeva LA, Miasoedov NF. Antiviral activity of immunomodulator Selank in experimental influenza infection. Vopr Virusol. 2009;54(5):19-24. PMID: 19882898. PMID 19882898 | research article |
| 2008 | N-Acetyl Selank | Zozulia AA, Neznamov GG, Siuniakov TS, Kost NV, Gabaeva MV, Sokolov OIu, Serebriakova EV, Siranchieva OA, Andriushenko AV, Telesheva ES, Siuniakov SA, Smulevich AB, Miasoedov NF, Seredenin SB. Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the t… PMID 18454096 | research article |
| 2003 | N-Acetyl Selank | Kozlovskaya MM, Kozlovskii II, Val'dman EA, Seredenin SB. Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress. Neurosci Behav Physiol. 2003;33(9):853-860. PMID: 14969428. PMID 14969428 | research article |
| 2002 | Semax | Skvortsova VI, Platonova IA, Tvorogova TV, Miasoedov NF. Effect of semax on disability and handicap indexes in patients survived carotid ischemic stroke. Zh Nevrol Psikhiatr Im S S Korsakova. 2002;102(Suppl 5):36-39. | human study |
| 2020 | Semax | Filippenkov IB, Stavchansky VV, Denisova AE, et al. Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats. Genes (Basel). 2020;11(6):681. | preclinical, in vivo |
| 2013 | Semax | Glazova NY, Sebentsova EA, Manchenko DM, et al. Prolonged beneficial effect of neonatal treatment with Semax on the grooming behavior of elderly rats. Bull Exp Biol Med. 2013;155(6):731-733. | preclinical, in vivo |
| 2011 | Semax | Stavchansky VV, Tvorogova TV, Botsina AY, Skvortsova VI, Limborska SA, Myasoedov NF, Dergunova LV. The effect of Semax and its C-end peptide PGP on expression of neurotrophins and their receptors in rat brain during incomplete global ischemia. Mol Biol (Mosk). 2011;45(6):1026-10… | preclinical, in vivo |
| 2010 | Semax | Shadrina M, Kolomin T, Agapova T, et al. Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina under Semax action. J Mol Neurosci. 2010;41(1):30-35. | preclinical, in vivo |
| 2007 | Semax | Agapova TY, Agniullin YV, Shadrina MI, Shram SI, Slominsky PA, Lymborska SA, Myasoedov NF. Neurotrophin gene expression in rat brain under the action of Semax, an analogue of ACTH(4-10). Neurosci Lett. 2007;417(2):201-205. | preclinical, in vivo |
| 2007 | Semax | Storozheva ZI, Proshin AT, Sherstnev VV, Stolyarov ID, Boĭko AN. Effects of Semax on different forms of learning and memory in adult and aged rats. Bull Exp Biol Med. 2007;143(4):482-485. | preclinical, in vivo |
| 2006 | Semax | Dolotov OV, Karpenko EA, Inozemtseva LS, et al. Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain. J Neurochem. 2006;97 Suppl 1:82-86. PMID: 16635254. PMID 16635254 | preclinical, in vivo |
| 2006 | Semax | Volkova MV, Shadrina MI, Kolomin TA, Dolotov OV, Grivennikov IA, Shaburova EV, Solntseva OS, Myasoedov NF, Limborska SA, Slominsky PA. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res. 2006;1117(1):54-60.… PMID 16996037 | preclinical, in vivo |
| 1991 | Semax | Potaman VN, Antonova LV, Dubynin VA, et al. Entry of the synthetic ACTH(4-10) analogue into the rat brain following intravenous injection. Neurosci Lett. 1991;130(1):11-13. | preclinical, in vivo |
| 1997 | Semax | Gusev EI, Skvortsova VI, Miasoedov NF, Nezavibatko VN, Zhuravleva EIu, Vanichkin AV. [Effectiveness of semax in acute period of hemispheric ischemic stroke (a clinical and electrophysiological study)]. Zh Nevrol Psikhiatr Im S S Korsakova. 1997;97(6):26-34. PMID: 11517472. PMID 11517472 | research article |
Related pair pages
More research context
Frequently asked
Have N-Acetyl Selank and Semax been studied together?
Researchers have published mechanistic-level co-administration discussion of N-Acetyl Selank and Semax. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do N-Acetyl Selank and Semax share?
N-Acetyl Selank and Semax do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of N-Acetyl Selank and Semax?
N-Acetyl Selank: Not listed. Semax: Not approved. FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on N-Acetyl Selank and Semax?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the N-Acetyl Selank profile and the Semax profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026