Pair page
Palmitoyl Dipeptide-6 with Tripeptide-29
Mechanism-tag overlap and published literature for Palmitoyl Dipeptide-6 and Tripeptide-29, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
cosmetic-skin-firming-lipopeptide
cosmetic-collagen-fragment
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying Palmitoyl Dipeptide-6 and Tripeptide-29 have published these mechanism-level observations. Not a co-administration recommendation.
Palmitoyl-dipeptide and palmitoyl-tripeptide derivatives layer additional matrikine-class signals onto a Tripeptide-29 base. Each palmitoylated peptide carries a different sequence-specific signal; the lipidation improves dermal penetration of the peptide moiety. Typical multi-peptide cosmetic formulations include 3–6 different peptide species, each at low single-digit percent, on the rationale that combinatorial signaling outperforms single-peptide approaches.
Quick facts
Palmitoyl Dipeptide-6
Tripeptide-29
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2014 | Palmitoyl Dipeptide-6 | Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014;27(1):47-55. PMID: 23949208. (Oral collagen-pe… PMID 23949208 | human trial |
| 2012 | Palmitoyl Dipeptide-6 | Wakao T, Oyama H, Hara D, Nakaseko T, Kimura S, Wakabayashi H. Pilot study of topical acetyl hexapeptide-8 in the treatment for blepharospasm in patients receiving botulinum toxin therapy. J Rehabil Med. 2012;44(10):888-891. PMID: 23146065. (Small pilot demonstrating a cosmetic… PMID 23146065 | human pilot |
| 1993 | Palmitoyl Dipeptide-6 | Katayama K, Armendariz-Borunda J, Raghow R, Kang AH, Seyer JM. A pentapeptide from type I procollagen promotes extracellular matrix production. J Biol Chem. 1993;268(14):9941-9944. PMID: 8486721. (Founding in-vitro demonstration that the KTTKS pentapeptide stimulates type I coll… PMID 8486721 | preclinical, in vitro |
| 2013 | Palmitoyl Dipeptide-6 | Castelletto V, Hamley IW, Whitehouse C, Matts PJ, Osborne R, Baker ES. Self-Assembly of Palmitoyl Lipopeptides Used in Skin Care Products. Langmuir. 2013;29(29):9149-9155. DOI: 10.1021/la401771j. (Biophysical characterization of pal-KTTKS, pal-GHK, and pal-KT self-assembly — est… | mechanism / discovery |
| 2020 | Palmitoyl Dipeptide-6 | Errante F, Ledwoń P, Latajka R, Rovero P, Papini AM. Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Front Chem. 2020;8:572923. DOI: 10.3389/fchem.2020.572923. (Contemporary review of cosmeceutical peptide chemistry, delivery, and regulatory frameworks.… | review |
| 2017 | Palmitoyl Dipeptide-6 | Pai VV, Bhandari P, Shukla P. Topical peptides as cosmeceuticals. Indian J Dermatol Venereol Leprol. 2017;83(1):9-18. DOI: 10.4103/0378-6323.186500. (Narrative review of topical peptide cosmeceuticals including palmitoyl lipopeptides; evaluates evidence and regulatory framework… | review |
| 2011 | Palmitoyl Dipeptide-6 | Abu Samah NH, Heard CM. Topically applied KTTKS: a review. Int J Cosmet Sci. 2011;33(6):483-490. PMID: 21535443. (Comprehensive academic review of KTTKS and its major derivatives including palmitoylated forms. Addresses physicochemical properties, theoretical skin permeation, an… PMID 21535443 | review |
| 2009 | Palmitoyl Dipeptide-6 | Gorouhi F, Maibach HI. Role of topical peptides in preventing or treating aged skin. Int J Cosmet Sci. 2009;31(5):327-345. DOI: 10.1111/j.1468-2494.2009.00490.x. (Review of topical peptide cosmetics with evidence-rating discussion across the signal / neurotransmitter / carrier p… | review |
| 2009 | Palmitoyl Dipeptide-6 | Fields K, Falla TJ, Rodan K, Bush L. Bioactive peptides: signaling the future. J Cosmet Dermatol. 2009;8(1):8-13. DOI: 10.1111/j.1473-2165.2009.00416.x. (Review of bioactive peptides in dermatology, including discussion of signal peptides and palmitoyl lipopeptides as the leadin… | review |
| 2009 | Palmitoyl Dipeptide-6 | Zhang L, Falla TJ. Cosmeceuticals and peptides. Clin Dermatol. 2009;27(5):485-494. DOI: 10.1016/j.clindermatol.2009.05.013. (Review specifically on cosmetic peptides from a dermatology-clinic perspective, addressing the signal-peptide class including palmitoylated variants.) | review |
| 2000 | Palmitoyl Dipeptide-6 | Lintner K, Peschard O. Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. Int J Cosmet Sci. 2000;22(3):207-218. PMID: 18503476. (Sederma's foundational review establishing the cosmetic-lipopeptide strategic framework — palmitoylati… PMID 18503476 | industry documentation |
| 2007 | Palmitoyl Dipeptide-6 | Lupo MP, Cole AL. Cosmeceutical peptides. Dermatol Ther. 2007;20(5):343-349. PMID: 18045359. (Dermatology-review classification of cosmetic peptides into signal, neurotransmitter-affecting, and carrier categories. Notes the limited efficacy-testing rigor of the field as a whole.) PMID 18045359 | research article |
| 2019 | Tripeptide-29 | Choi FD, Sung CT, Juhasz ML, Mesinkovsk NA. Oral Collagen Supplementation: A Systematic Review of Dermatological Applications. J Drugs Dermatol. 2019;18(1):9-16. PMID: 30681787. (Systematic review of 11 RCTs of oral collagen supplementation, 805 patients; includes 2 collagen tri… PMID 30681787 | systematic review |
| 2022 | Tripeptide-29 | Kim J, Lee SG, Lee J, Choi S, Suk J, Lee JH, Yang JH, Yang JS, Kim J. Oral Supplementation of Low-Molecular-Weight Collagen Peptides Reduces Skin Wrinkles and Improves Biophysical Properties of Skin: A Randomized, Double-Blinded, Placebo-Controlled Study. J Med Food. 2022;25(12)… PMID 36516059 | human trial |
| 2019 | Tripeptide-29 | Bolke L, Schlippe G, Gerß J, Voss W. A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study. Nutrients. 2019;11(10):2494. PMID: 31627309. doi: 10.3390/nu11102494. (Multi-ingredient nutricosmetic… PMID 31627309 | human trial |
| 2018 | Tripeptide-29 | Kim DU, Chung HC, Choi J, Sakai Y, Lee BY. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2018;10(7):826. doi: 10.3390/nu10070826. (Oral LMWCP prep… | human trial |
| 2015 | Tripeptide-29 | Asserin J, Lati E, Shioya T, Prawitt J. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol. 2015;14(4):291-301. PMID: 26362110.… PMID 26362110 | human trial |
| 2022 | Tripeptide-29 | Taga Y, Iwasaki Y, Shigemura Y, Mizuno K. Identification of a Highly Stable Bioactive 3-Hydroxyproline-Containing Tripeptide in Human Blood after Collagen Hydrolysate Ingestion. npj Sci Food. 2022;6(1):29. (Identification of Gly-3Hyp-4Hyp as a stable bioactive collagen tripeptid… | human study |
| 2017 | Tripeptide-29 | Hexsel D, Zague V, Schunck M, Siega C, Camargo FB Jr, Oesser S. Oral supplementation of specific bioactive collagen peptides reduces skin wrinkles and improves nail growth in women. J Cosmet Dermatol. 2017;16(4):520-526. PMID: 28786550. (Oral bioactive collagen peptides RCT in n… PMID 28786550 | human study |
| 2005 | Tripeptide-29 | Iwai K, Hasegawa T, Taguchi Y, Morimatsu F, Sato K, Nakamura Y, Higashi A, Kido Y, Nakabo Y, Ohtsuki K. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. J Agric Food Chem. 2005;53(16):6531-6536. PMID: 16076145. doi: 10… PMID 16076145 | human study |
| 2020 | Tripeptide-29 | Asai TT, Yoshikawa K, Sawada K, Fukamizu K, Koyama YI, Shigemura Y, Jimi S, Sato K. Mouse skin fibroblasts with mesenchymal stem cell marker p75 neurotrophin receptor proliferate in response to prolyl-hydroxyproline. J Funct Foods. 2020;66:103792. (p75NTR-positive fibroblast sub… | preclinical, in vivo |
| 2019 | Tripeptide-29 | Asai TT, Oikawa F, Yoshikawa K, Inoue N, Sato K. Food-Derived Collagen Peptides, Prolyl-Hydroxyproline (Pro-Hyp), and Hydroxyprolyl-Glycine (Hyp-Gly) Enhance Growth of Primary Cultured Mouse Skin Fibroblast Using Fetal Bovine Serum Free from Hydroxyprolyl Peptide. Int J Mol Sci.… | preclinical, in vivo |
| 2016 | Tripeptide-29 | Sontakke SB, Jung JH, Piao Z, Chung HJ. Orally Available Collagen Tripeptide: Enzymatic Stability, Intestinal Permeability, and Absorption of Gly-Pro-Hyp and Pro-Hyp. J Agric Food Chem. 2016;64(38):7127-7133. PMID: 27573716. (Differential bioavailability of GPH vs Pro-Hyp; biotr… PMID 27573716 | preclinical, in vivo |
| 2015 | Tripeptide-29 | Yamamoto S, Hayasaka F, Deguchi K, Okudera T, Furusawa T, Sakai Y. Absorption and plasma kinetics of collagen tripeptide after peroral or intraperitoneal administration in rats. Biosci Biotechnol Biochem. 2015;79(12):2026-2033. (Pharmacokinetic study of Gly-Pro-Hyp absorption af… | preclinical, in vivo |
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Frequently asked
Have Palmitoyl Dipeptide-6 and Tripeptide-29 been studied together?
Researchers have published mechanistic-level co-administration discussion of Palmitoyl Dipeptide-6 and Tripeptide-29. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do Palmitoyl Dipeptide-6 and Tripeptide-29 share?
Palmitoyl Dipeptide-6 and Tripeptide-29 do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of Palmitoyl Dipeptide-6 and Tripeptide-29?
Palmitoyl Dipeptide-6: Cosmetic ingredient. Tripeptide-29: Cosmetic ingredient (no premarket approval). FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on Palmitoyl Dipeptide-6 and Tripeptide-29?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the Palmitoyl Dipeptide-6 profile and the Tripeptide-29 profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026