Pair page
Cardiogen with Vesugen
Mechanism-tag overlap and published literature for Cardiogen and Vesugen, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
khavinson-cardiac-bioregulator
khavinson-short-peptide-bioregulatorvascular
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying Cardiogen and Vesugen have published these mechanism-level observations. Not a co-administration recommendation.
Vesugen is the Khavinson vascular-endothelial bioregulator (KED). Pairing Cardiogen (myocardium) and Vesugen (vessels) is a common community practice within the longevity-focused Khavinson stack — the two compartments most relevant to cardiovascular aging. Neither is a clinically validated cardiovascular therapy.
Khavinson-framework short peptide targeting cardiac myocytes rather than vascular endothelium. Cardiogen + Vesugen is the Khavinson "cardiac + vascular" combination.
Quick facts
Cardiogen
Vesugen
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2021 | Cardiogen | Khavinson VKh, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053. PMID: 34834147. DOI: 10.3390/molecules26227053. PMID 34834147 | systematic review |
| 2006 | Cardiogen | Gumen AV, Kozinets IA, Shanin SN, Malinin VV, Rybakina EG. Production of lymphocyte-activating factors by mouse macrophages during aging and under the effect of short peptides. Bulletin of Experimental Biology and Medicine. 2006;142(3):360-362. PMID: 17266159. PMID 17266159 | preclinical, in vivo |
| 2001 | Cardiogen | Anisimov VN, Khavinson VKh, Mylnikov SV. Effect of synthetic dipeptide Thymogen (Glu-Trp) on life span and spontaneous tumor incidence in rats. Mech Ageing Dev. 2001;122(1):41-68. PMID: 11110629. (Program methodology reference.) PMID 11110629 | preclinical, in vivo |
| 2016 | Cardiogen | Linkova NS, Drobintseva AO, Orlova OA, Kuznetsova EP, Polyakova VO, Kvetnoy IM, Khavinson VKh. Peptide regulation of skin fibroblast functions during their aging in vitro. Bulletin of Experimental Biology and Medicine. 2016;161(1):175-178. PMID: 27259486. (Sibling tissue-specifi… PMID 27259486 | preclinical, in vitro |
| 2011 | Cardiogen | Fedoreyeva LI, Kireev II, Khavinson VKh, Vanyushin BF. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and the specific interaction of the peptides with deoxyribooligonucleotides and DNA in vitro. Biochemistry (Moscow). 2011;76(11):1210-1219. PM… PMID 22117548 | preclinical, in vitro |
| 2012 | Cardiogen | Khavinson VKh, Solov'ev AIu, Zhilinskii DV. Molecular mechanism of the peptide regulation of gene expression: a review. Advances in Gerontology. 2012;25(3):447-456. PMID: 23289233. PMID 23289233 | mechanism / discovery |
| 2003 | Cardiogen | Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine. 2003;135(6):590-592. PMID: 12937682. (Sibling-peptide methodology reference.) PMID 12937682 | mechanism / discovery |
| 2020 | Cardiogen | Khavinson V, Linkova N, Diatlova A, Trofimova S. Peptide Regulation of Cell Differentiation. Stem Cell Reviews and Reports. 2020;16(1):118-125. PMID: 31813120. DOI: 10.1007/s12015-019-09938-8. PMID 31813120 | bioregulator literature |
| 2016 | Cardiogen | Vanyushin BF, Khavinson VKh. Short Biologically Active Peptides as Epigenetic Modulators of Gene Activity. In: Doerfler W, Casadesús J (eds), Epigenetics — A Different Way of Looking at Genetics. Springer, 2016. DOI: 10.1007/978-3-319-27186-6_5. | bioregulator literature |
| 2013 | Cardiogen | Ivanov EI, Khavinson VKh. Peptide bioregulation and cardiovascular pathology. Advances in Gerontology. 2013;3(4):267-273. (Program-level cardiovascular framing.) | bioregulator literature |
| 2012 | Cardiogen | Khavinson VKh, Linkova NS, Polyakova VO, Kheifets OV, Tarnovskaya SI, Kvetnoy IM. Peptides tissue-specifically stimulate cell differentiation during their aging. Bulletin of Experimental Biology and Medicine. 2012;153(1):148-151. PMID: 22808513. PMID 22808513 | bioregulator literature |
| 2010 | Cardiogen | Anisimov VN, Khavinson VKh. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010;11(2):139-149. PMID: 19633997. PMID 19633997 | bioregulator literature |
| 2021 | Vesugen | Khavinson VKh, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide regulation of gene expression: a systematic review. Molecules. 2021;26(22):7053. PMID: 34834146. PMID 34834146 | systematic review |
| 2016 | Vesugen | Linkova NS, Drobintseva AO, Orlova OA, Kuznetsova EP, Polyakova VO, Kvetnoy IM, Khavinson VKh. Peptide regulation of skin fibroblast functions during their aging in vitro. Bull Exp Biol Med. 2016;161(1):175-178. PMID: 27265131. PMID 27265131 | preclinical, in vitro |
| 2016 | Vesugen | Khavinson VKh, Linkova NS, Tarnovskaya SI. Short peptides regulate gene expression. Bull Exp Biol Med. 2016;162(2):288-292. PMID: 27905024. PMID 27905024 | mechanism / discovery |
| 2014 | Vesugen | Khavinson VKh, Tendler SM, Vanyushin BF, Kasyanenko NA, Kvetnoy IM, Linkova NS, et al. Peptide regulation of gene expression and protein synthesis in bronchial epithelium. Lung. 2014;192(5):781-791. PMID: 24920421. PMID 24920421 | mechanism / discovery |
| 2025 | Vesugen | World Anti-Doping Agency. 2025 WADA Prohibited List. WADA, 2025. | regulatory / registry |
| 2022 | Vesugen | Khavinson V, Linkova N, Umnov R. Peptide KED: biological activity and mechanisms of action. Int J Mol Sci. 2022;23(2):852. (KED sequence biology review.) | bioregulator literature |
| 2013 | Vesugen | Khavinson VKh, Kuznik BI, Ryzhak GA. Peptide bioregulators: a new class of geroprotectors. Report 1. Adv Gerontol. 2013;3(2):83-93. | bioregulator literature |
| 2013 | Vesugen | Linkova NS, Kuznik BI, Khavinson VKh. Peptide bioregulators in vascular aging. Advances in Gerontology. 2013;3(4):267-273. | bioregulator literature |
| 2012 | Vesugen | Kuznik BI, Khavinson VKh, Linkova NS. Heat shock proteins, peptide bioregulators, and aging. Adv Gerontol. 2012;25(3):371-380. | bioregulator literature |
| 2010 | Vesugen | Anisimov VN, Khavinson VKh. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010;11(2):139-149. PMID: 19609712. PMID 19609712 | bioregulator literature |
| 2005 | Vesugen | Khavinson VKh, Malinin VV. Gerontological Aspects of Genome Peptide Regulation. Karger, Basel, 2005. | bioregulator literature |
| 2003 | Vesugen | Khavinson VKh, Morozov VG. Peptides of pineal gland and thymus prolong human life. Neuro Endocrinol Lett. 2003;24(3-4):233-240. PMID: 14523363. PMID 14523363 | bioregulator literature |
Related pair pages
More research context
Frequently asked
Have Cardiogen and Vesugen been studied together?
Researchers have published mechanistic-level co-administration discussion of Cardiogen and Vesugen. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do Cardiogen and Vesugen share?
Cardiogen and Vesugen do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of Cardiogen and Vesugen?
Cardiogen: Not approved. Vesugen: Not approved. FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on Cardiogen and Vesugen?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the Cardiogen profile and the Vesugen profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026