Pair page
Epithalon with Pancragen
Mechanism-tag overlap and published literature for Epithalon and Pancragen, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
pineal-tetrapeptide-khavinson-bioregulator
khavinson-pancreatic-bioregulator
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying Epithalon and Pancragen have published these mechanism-level observations. Not a co-administration recommendation.
Canonical Khavinson-framework combination. Alternating courses of Pancragen (metabolic) and Epithalon (systemic longevity) is standard within the bioregulator paradigm. Both use 10–20 day pulse courses with 3–6 month intervals.
Quick facts
Epithalon
Pancragen
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2010 | Epithalon | Korkushko OV, Khavinson VKh, Shatilo VB, Antonyk-Sheglova IA. Peptide geroprotector Epitalamin: effects on vascular endothelial function in elderly patients. Adv Gerontol. 2010;23(3):440-446. | human study |
| 2004 | Epithalon | Khavinson VKh, Bondarev IE, Butyugov AA, Smirnova TD. Peptide promotes overcoming of the division limit in human somatic cell. Bull Exp Biol Med. 2004;137(5):503-506. | human study |
| 2003 | Epithalon | Khavinson VKh, Morozov VG. Peptides of pineal gland and thymus prolong human life. Neuro Endocrinol Lett. 2003;24(3-4):233-240. PMID: 14523363. (266-patient elderly mortality cohort.) PMID 14523363 | human study |
| 2021 | Epithalon | Khavinson V, Ilina A, Kraskovskaya N, Linkova N, Kolchina N, Mikhailova N, Petukhov M. Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease. Pharmaceuticals (Basel). 2021;14(6):515. | preclinical, in vivo |
| 2004 | Epithalon | Labunets IF, Butenko GM, Dragunova VA, Magdich LV, Khavinson VKh. Effect of epithalamin, thymalin, and tocopherol on age-associated involution of the pineal gland in rats. Bull Exp Biol Med. 2004;137(5):510-512. | preclinical, in vivo |
| 2003 | Epithalon | Anisimov VN, Khavinson VKh, Provinciali M, Alimova IN, Baturin DA, Popovich IG, Zabezhinski MA, Imyanitov EN, Mancini R, Franceschi C. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4)… PMID 14501183 | preclinical, in vivo |
| 2003 | Epithalon | Kossoy G, Zandbank J, Tendler E, Anisimov V, Khavinson V, Popovich I, Zabezhinski M, Zusman I, Ben-Hur H. Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa. Int J Mol Med. 2003;12(4):473-477. PMID: 12964019. PMID 12964019 | preclinical, in vivo |
| 2025 | Epithalon | Al-Dulaimi MS, et al. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. 2025. PMID: 40908429. PMC12411320. (Modern Western-lab replication of the central telomerase-activation claim.) PMID 40908429 | mechanism / discovery |
| 2017 | Epithalon | Khavinson V, Popovich I. Short peptides regulate gene expression, protein synthesis and enhance life span. In: Understanding the Aging Process and Age-Related Diseases. Academic Press; 2017. | mechanism / discovery |
| 2016 | Epithalon | Khavinson VKh, Linkova NS, Tarnovskaia SI. Short peptides regulate gene expression. Bull Exp Biol Med. 2016;162(2):288-292. | mechanism / discovery |
| 2003 | Epithalon | Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells. Bull Exp Biol Med. 2003;135(6):590-592. PMID: 12937682. PMID 12937682 | mechanism / discovery |
| 2017 | Epithalon | Khavinson VKh, Kopylov AT, Vaskovsky BV, Ryzhak GA, Lin'kova NS. Identification of peptide AEDG in the polypeptide complex of the pineal gland. Bull Exp Biol Med. 2017;164(1):41-43. | bioregulator literature |
| 2021 | Pancragen | Khavinson V, Popovich I, Linkova N, Mironova E, Ilina A. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053. PMID: 34834146. PMID 34834146 | systematic review |
| 2020 | Pancragen | Khavinson VKh, Kuznik BI, Trofimova SV, Lin'kova NS. Cortexin and its short peptides AEDG and EDR modulate gene expression of proteins in pathogenesis of Alzheimer's disease. Biomed Khim. 2020. (Parallel framework evidence for the Khavinson short-peptide gene-expression paradigm… | mechanism / discovery |
| 2020 | Pancragen | Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis. Int J Mol Sci. 2020;21(2):609. PMID: 31963526. PMID 31963526 | mechanism / discovery |
| 2015 | Pancragen | Ashapkin VV, Linkova NS, Khavinson VKh, Vanyushin BF. Epigenetic Mechanisms of Peptidergic Regulation of Gene Expression during Aging of Human Cells. Biochemistry (Mosc). 2015;80(3):310-322. PMID: 25761684. PMID 25761684 | mechanism / discovery |
| 2020 | Pancragen | Khavinson VK. Peptide regulation of ageing: 40 years of research. Adv Gerontol. 2020. (Retrospective review of the Khavinson peptide program; Pancragen placed in context.) | review |
| 2022 | Pancragen | Khavinson VK, Kuznik BI, Lin'kova NS, et al. Peptide Medicines: Past, Present, Future. Clin Med (Russian Journal). 2022;100(1):5-13. (Comprehensive framework review placing Pancragen in broader bioregulator context.) | bioregulator literature |
| 2022 | Pancragen | Khavinson VKh, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide regulation of aging: methodology and evidence. Bull Exp Biol Med. 2022. | bioregulator literature |
| 2020 | Pancragen | Khavinson V, Linkova N, Diatlova A, Trofimova S. Peptide Regulation of Cell Differentiation, Proliferation, and Apoptosis. Adv Gerontol. 2020;10(2):98-106. | bioregulator literature |
| 2019 | Pancragen | Kolchina N, Khavinson V, Linkova N, Yakutseni P, Petukhov M, Morozova E, Ashapkin V. Systematic search for structural motifs of peptide binding to double-stranded DNA. Nucleic Acids Res. 2019;47(20):10553-10563. PMID: 31584079. PMID 31584079 | bioregulator literature |
| 2015 | Pancragen | Linkova NS, Drobintseva AO, Orlova OA, et al. Peptide regulation of beta-cell function during aging. Adv Gerontol. 2015;28(3):478-484. | bioregulator literature |
| 2005 | Pancragen | Khavinson VKh, Malinin VV. Gerontological Aspects of Genome Peptide Regulation. Karger; Basel; 2005. (Monograph; framework reference for all Khavinson peptides including Pancragen.) | bioregulator literature |
Related pair pages
More research context
Frequently asked
Have Epithalon and Pancragen been studied together?
Researchers have published mechanistic-level co-administration discussion of Epithalon and Pancragen. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do Epithalon and Pancragen share?
Epithalon and Pancragen do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of Epithalon and Pancragen?
Epithalon: Not approved. Pancragen: Not approved. FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on Epithalon and Pancragen?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the Epithalon profile and the Pancragen profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026