Pair page
HCG with Testosterone
Mechanism-tag overlap and published literature for HCG and Testosterone, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
glycoprotein-gonadotropinhormonelh-analog
androgenprimary-male-sex-hormone
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying HCG and Testosterone have published these mechanism-level observations. Not a co-administration recommendation.
HCG is the most common TRT adjunct. Testosterone provides the exogenous androgen replacement; hCG maintains testicular function, ITT, spermatogenesis, and neurosteroid production. Standard of care at most progressive men's-health clinics. Typical protocol: testosterone cypionate 100–200 mg/week + hCG 500 IU 2–3× weekly SubQ.
Quick facts
HCG
Testosterone
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2014 | HCG | Rastrelli G, Corona G, Mannucci E, Maggi M. Factors affecting spermatogenesis upon gonadotropin-replacement therapy: a meta-analytic study. Andrology. 2014;2(6):794-808. PMID: 25099686. (Meta-analysis of spermatogenesis response to gonadotropin replacement — relevant to hCG/FSH… PMID 25099686 | meta-analysis |
| 2018 | HCG | Bhasin S, Brito JP, Cunningham GR, Hayes FJ, Hodis HN, Matsumoto AM, Snyder PJ, Swerdloff RS, Wu FC, Yialamas MA. Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018;103(5):1715-1744. PMID: 29562364. (Soc… PMID 29562364 | human study |
| 2013 | HCG | Hsieh TC, Pastuszak AW, Hwang K, Lipshultz LI. Concomitant intramuscular human chorionic gonadotropin preserves spermatogenesis in men undergoing testosterone replacement therapy. J Urol. 2013;189(2):647-650. PMID: 23260550. PMID 23260550 | human study |
| 2013 | HCG | Kaminetsky J, Werner M, Fontenot G, Wiehle RD. Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel. J Sex Med. 2013;10(6):1628-1635. PMID: 23530575. (Adjacent SERM-based ax… PMID 23530575 | human study |
| 2026 | HCG | WADA. 2026 World Anti-Doping Code Prohibited List. Section S2 — Peptide hormones, growth factors, related substances, and mimetics. World Anti-Doping Agency. (hCG specifically prohibited in males.) | regulatory / registry |
| 2000 | HCG | U.S. Food and Drug Administration. Ovidrel (choriogonadotropin alfa) Prescribing Information. EMD Serono. First approved 2000. | regulatory / registry |
| — | HCG | U.S. Food and Drug Administration. Pregnyl (chorionic gonadotropin) Prescribing Information. Organon USA Inc. | regulatory / registry |
| — | HCG | U.S. Food and Drug Administration. Novarel (chorionic gonadotropin) Prescribing Information. Ferring Pharmaceuticals. | regulatory / registry |
| 2018 | HCG | Lee JA, Ramasamy R. Indications for the use of human chorionic gonadotropic hormone for the management of infertility in hypogonadal men. Transl Androl Urol. 2018;7(Suppl 3):S348-S352. PMID: 30050800. PMID 30050800 | research article |
| 2017 | HCG | Shiraishi K, Matsuyama H. Gonadotoropin actions on spermatogenesis and hormonal therapies for spermatogenic disorders. Endocr J. 2017;64(2):123-131. PMID: 28100858. PMID 28100858 | research article |
| 2015 | HCG | Ramasamy R, Armstrong JM, Lipshultz LI. Preserving fertility in the hypogonadal patient: an update. Asian J Androl. 2015;17(2):197-200. PMID: 25652635. PMID 25652635 | research article |
| 2013 | HCG | Crosnoe LE, Grober E, Ohl D, Kim ED. Exogenous testosterone: a preventable cause of male infertility. Transl Androl Urol. 2013;2(2):106-113. PMID: 26813847. (Mechanism and clinical framing of TRT-induced infertility and hCG-based prevention.) PMID 26813847 | research article |
| 2007 | Testosterone | Haddad RM, Kennedy CC, Caples SM, Tracz MJ, Boloña ER, Sideras K, Uraga MV, Erwin PJ, Montori VM. Testosterone and cardiovascular risk in men: a systematic review and meta-analysis. Mayo Clin Proc. 2007;82(1):29-39. PMID: 17285783. PMID 17285783 | systematic review |
| 2015 | Testosterone | Kaminetsky J, Jaffe JS, Swerdloff RS. Pharmacokinetic Profile of Subcutaneous Testosterone Enanthate Delivered via a Novel, Prefilled Single-Use Autoinjector: A Phase II Study. Sex Med. 2015;3(4):269-279. PMID: 26797061. PMC4721027. PMID 26797061 | human trial, Phase 2 |
| 2013 | Testosterone | Finkelstein JS, Lee H, Burnett-Bowie SA, Pallais JC, Yu EW, Borges LF, Jones BF, Barry CV, Wulczyn KE, Thomas BJ, Leder BZ. Gonadal steroids and body composition, strength, and sexual function in men. N Engl J Med. 2013;369(11):1011-1022. PMID: 24024838. PMID 24024838 | human study |
| 2008 | Testosterone | Coviello AD, Kaplan B, Lakshman KM, Chen T, Singh AB, Bhasin S. Effects of graded doses of testosterone on erythropoiesis in healthy young and older men. J Clin Endocrinol Metab. 2008;93(3):914-919. PMID: 18160461. PMID 18160461 | human study |
| 2001 | Testosterone | Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR; Baltimore Longitudinal Study of Aging. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab. 2001;86(2):724-731. PMID: 11158037. PMID 11158037 | human study |
| 2025 | Testosterone | WADA. 2025 Prohibited List. Section S1 — Anabolic Agents. World Anti-Doping Agency. | regulatory / registry |
| 2023 | Testosterone | Lincoff AM, Bhasin S, Flevaris P, Mitchell LM, Basaria S, Boden WE, Cunningham GR, Granger CB, Khera M, Thompson IM Jr, Wang Q, Wolski K, Davey D, Kalahasti V, Khan N, Miller MG, Snabes MC, Chan A, Dubcenco E, Li X, Yi T, Huang B, Pencina KM, Travison TG, Nissen SE; TRAVERSE Stu… PMID 37326322 | research article |
| 2018 | Testosterone | Mulhall JP, Trost LW, Brannigan RE, Kurtz EG, Redmon JB, Chiles KA, Lightner DJ, Miner MM, Murad MH, Nelson CJ, Platz EA, Ramanathan LV, Lewis RW. Evaluation and Management of Testosterone Deficiency: AUA Guideline. J Urol. 2018;200(2):423-432. PMID: 29601923. PMID 29601923 | research article |
| 2016 | Testosterone | Snyder PJ, Bhasin S, Cunningham GR, et al. Effects of Testosterone Treatment in Older Men. N Engl J Med. 2016;374(7):611-624. PMID: 26886521. PMID 26886521 | research article |
| 2016 | Testosterone | Morgentaler A, Zitzmann M, Traish AM, Fox AW, Jones TH, Maggi M, Arver S, Aversa A, Chan JC, Dobs AS, Hackett GI, Hellstrom WJ, Lim P, Lunenfeld B, Mskhalaya G, Schulman CC, Torres LO. Fundamental Concepts Regarding Testosterone Deficiency and Treatment: International Expert Con… PMID 27313122 | research article |
| 2016 | Testosterone | Shoskes JJ, Wilson MK, Spinner ML. Pharmacology of testosterone replacement therapy preparations. Transl Androl Urol. 2016;5(6):834-843. PMID: 28078214. PMID 28078214 | research article |
| 2011 | Testosterone | Jones TH, Arver S, Behre HM, Buvat J, Meuleman E, Moncada I, Morales AM, Volterrani M, Yellowlees A, Howell JD, Channer KS; TIMES2 Investigators. Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 study). Diabetes Care. 2011;34… PMID 21386088 | research article |
Related pair pages
More research context
Frequently asked
Have HCG and Testosterone been studied together?
Researchers have published mechanistic-level co-administration discussion of HCG and Testosterone. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do HCG and Testosterone share?
HCG and Testosterone do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of HCG and Testosterone?
HCG: Approved (hypogonadism, cryptorchidism, infertility). Testosterone: Approved (multiple formulations). FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on HCG and Testosterone?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the HCG profile and the Testosterone profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026