Pair page
Pancragen with Thymalin
Mechanism-tag overlap and published literature for Pancragen and Thymalin, pulled verbatim from each Kalios compound profile. Kalios is a literature reference, not a recommendation.
Mechanism overlap
Mechanism tags are verbatim labels on each compound's profile. Generic tags ("peptide", "small-molecule", "research-chemical") are excluded from this overlap view. Tags are descriptive — not an inference about combined effect.
khavinson-pancreatic-bioregulator
thymic-polypeptide-bioregulator-complex
Co-administration notes from the literature
Verbatim summary text pulled from each compound's profile data. Researchers studying Pancragen and Thymalin have published these mechanism-level observations. Not a co-administration recommendation.
Thymus-targeted Khavinson peptide. Metabolic disease involves low-grade systemic inflammation in which thymic function contributes; pairing Pancragen (pancreas) with Thymalin (immune) is part of some aging-framework protocols.
Quick facts
Pancragen
Thymalin
Literature table
Classified references from each compound profile. Click a column header to sort. Click a PMID to open PubMed. Findings are quoted verbatim from each profile's literature_summary; nothing here is added or interpreted.
| Year | Compound | Source | Finding |
|---|---|---|---|
| 2021 | Pancragen | Khavinson V, Popovich I, Linkova N, Mironova E, Ilina A. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053. PMID: 34834146. PMID 34834146 | systematic review |
| 2020 | Pancragen | Khavinson VKh, Kuznik BI, Trofimova SV, Lin'kova NS. Cortexin and its short peptides AEDG and EDR modulate gene expression of proteins in pathogenesis of Alzheimer's disease. Biomed Khim. 2020. (Parallel framework evidence for the Khavinson short-peptide gene-expression paradigm… | mechanism / discovery |
| 2020 | Pancragen | Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis. Int J Mol Sci. 2020;21(2):609. PMID: 31963526. PMID 31963526 | mechanism / discovery |
| 2015 | Pancragen | Ashapkin VV, Linkova NS, Khavinson VKh, Vanyushin BF. Epigenetic Mechanisms of Peptidergic Regulation of Gene Expression during Aging of Human Cells. Biochemistry (Mosc). 2015;80(3):310-322. PMID: 25761684. PMID 25761684 | mechanism / discovery |
| 2020 | Pancragen | Khavinson VK. Peptide regulation of ageing: 40 years of research. Adv Gerontol. 2020. (Retrospective review of the Khavinson peptide program; Pancragen placed in context.) | review |
| 2022 | Pancragen | Khavinson VK, Kuznik BI, Lin'kova NS, et al. Peptide Medicines: Past, Present, Future. Clin Med (Russian Journal). 2022;100(1):5-13. (Comprehensive framework review placing Pancragen in broader bioregulator context.) | bioregulator literature |
| 2022 | Pancragen | Khavinson VKh, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide regulation of aging: methodology and evidence. Bull Exp Biol Med. 2022. | bioregulator literature |
| 2020 | Pancragen | Khavinson V, Linkova N, Diatlova A, Trofimova S. Peptide Regulation of Cell Differentiation, Proliferation, and Apoptosis. Adv Gerontol. 2020;10(2):98-106. | bioregulator literature |
| 2019 | Pancragen | Kolchina N, Khavinson V, Linkova N, Yakutseni P, Petukhov M, Morozova E, Ashapkin V. Systematic search for structural motifs of peptide binding to double-stranded DNA. Nucleic Acids Res. 2019;47(20):10553-10563. PMID: 31584079. PMID 31584079 | bioregulator literature |
| 2015 | Pancragen | Linkova NS, Drobintseva AO, Orlova OA, et al. Peptide regulation of beta-cell function during aging. Adv Gerontol. 2015;28(3):478-484. | bioregulator literature |
| 2010 | Pancragen | Anisimov VN, Khavinson VKh. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010;11(2):139-149. PMID: 19633997. PMID 19633997 | bioregulator literature |
| 2005 | Pancragen | Khavinson VKh, Malinin VV. Gerontological Aspects of Genome Peptide Regulation. Karger; Basel; 2005. (Monograph; framework reference for all Khavinson peptides including Pancragen.) | bioregulator literature |
| 2021 | Thymalin | Khavinson VK, Kuznik BI, Tarnovskaya SI, Linkova NS. Results and Prospects of Using Activator of Hematopoietic Stem Cell Differentiation in Complex Therapy for Patients with COVID-19. Stem Cell Rev Rep. 2021 Feb;17(1):285-290. doi: 10.1007/s12015-020-10087-6. PMID: 33575961. (Re… PMID 33575961 | human study |
| 2020 | Thymalin | Khavinson V, Linkova N, Dyatlova A, Kuznik B, Umnov R. Peptides: Prospects for Use in the Treatment of COVID-19. Molecules. 2020 Sep 24;25(19):4389. doi: 10.3390/molecules25194389. PMID: 32987757. (Computational and mechanistic review of Khavinson short peptides — including the… PMID 32987757 | human study |
| 2020 | Thymalin | Khavinson VK, Kuznik BI, Volchkov VA, Rukavishnikova SA, Titova ON, Akhmedov TA, Trofimova SV, Ryzhak GA, Potyomkin VV, Saginbaev UR. Effect of thymalin on adaptive immunity in complex therapy for patients with COVID-19. Klinicheskaya Meditsina (Russian Journal). 2020;98(8):593-… | human study |
| 2020 | Thymalin | Lukyanov SA, Kuznik BI, Shapovalov KG, Khavinson VK, Smolyakov YN, et al. Thymalin as a Potential Alternative in the Treatment of Severe Acute Respiratory Infection Associated with SARS-CoV-2. Int J Immunol Immunother. 2020;7:055. (Severe-COVID-19 case treated with Thymalin 10 m… | human study |
| 1986 | Thymalin | Kuznik BI, Makhakova GCh, Morozov VG, Pisarevskaia LI, Khavinson VKh. [Effect of thymalin on thrombocyte aggregation and the antiaggregation activity of the vascular wall in intact and thymectomized rats]. Biull Eksp Biol Med. 1986 Aug;102(8):200-202. Russian. PMID: 3754821. (Ea… PMID 3754821 | preclinical, in vivo |
| 1982 | Thymalin | Anisimov VN, Khavinson VKh, Morozov VG. Carcinogenesis and aging. IV. Effect of low-molecular-weight factors of thymus, pineal gland and anterior hypothalamus on immunity, tumor incidence and life span of C3H/Sn mice. Mech Ageing Dev. 1982 Jul;19(3):245-258. doi: 10.1016/0047-63… | preclinical, in vivo |
| 2022 | Thymalin | Avolio F, Martinotti S, Khavinson VK, Esposito JE, Giambuzzi G, Marino A, Mironova E, Pulcini R, Robuffo I, Bologna G, Simeone P, Lanuti P, Guarnieri S, Trofimova S, Procopio AD, Toniato E. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macr… PMID 35408963 | preclinical, in vitro |
| 2020 | Thymalin | Khavinson VK, Linkova NS, Kvetnoy IM, Polyakova VO, Drobintseva AO, Kvetnaya TV, Ivko OM. Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells. Bull Exp Biol Med. 2020 Nov;170(1):118-122. doi: 10.1007/s10517-020-05016-z. PMID: 33237528. (In vitro demonstrati… PMID 33237528 | preclinical, in vitro |
| 2016 | Thymalin | Linkova NS, Drobintseva AO, Orlova OA, Kuznetsova EP, Polyakova VO, Kvetnoy IM, Khavinson VK. Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro. Bull Exp Biol Med. 2016 May;161(1):175-178. doi: 10.1007/s10517-016-3370-x. PMID: 27259484. (Khavinson short… PMID 27259484 | preclinical, in vitro |
| 2017 | Thymalin | Khavinson V, Popovich I. Short Peptides Regulate Gene Expression, Protein Synthesis and Enhance Life Span. In: Vaiserman AM (ed.). Anti-aging Drugs: From Basic Research to Clinical Practice. RSC Drug Discovery Series No. 57. Royal Society of Chemistry; 2017. Chapter 20, pp. 496–… | mechanism / discovery |
| 2016 | Thymalin | Khavinson VK, Lin'kova NS, Tarnovskaya SI. Short Peptides Regulate Gene Expression. Bull Exp Biol Med. 2016 Nov;162(2):288-292. doi: 10.1007/s10517-016-3596-7. PMID: 27909961. (Khavinson group's short-peptide DNA-binding / gene-expression-regulation hypothesis, the mechanistic f… PMID 27909961 | mechanism / discovery |
| 2021 | Thymalin | Khavinson VK, Linkova NS, Kvetnoy IM, Kvetnaia TV, Polyakova VO, Ashapkin VV. The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity. Front Pharmacol. 2021;12:716947. doi: 10.3389/fphar.2021.716947. PMC8365293. (Narrative review summarizing 6–12-ye… | review |
Related pair pages
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Frequently asked
Have Pancragen and Thymalin been studied together?
Researchers have published mechanistic-level co-administration discussion of Pancragen and Thymalin. No human co-administration trials are catalogued in the Kalios profiles. The pair page lists each compound's classified literature; full citations sit on each individual profile.
What mechanisms do Pancragen and Thymalin share?
Pancragen and Thymalin do not share a specific mechanism tag on their Kalios profiles. They appear on the same pair page because at least one profile lists the other in its co-administration data.
What is the FDA status of Pancragen and Thymalin?
Pancragen: Not approved. Thymalin: Not approved (US). FDA-status text is pulled verbatim from each compound profile. See /fda-pcac-2026.html for the broader FDA Pharmacy Compounding Advisory Committee context.
Where can I find the full research on Pancragen and Thymalin?
Full citation lists, dosing tables from the literature, reconstitution data, and the FDA / WADA status are on the individual compound profiles: the Pancragen profile and the Thymalin profile. The Kalios Stack Research Tool hub lists every compound covered.
Last updated: April 2026